Publications

Mitochondria in human neutrophils mediate killing of staphylococcus aureus.

Dunham-Snary KJ, Surewaard BGJ, Mewburn JD, Lima PDA, Jones O, Al-Qazazi R, Martin AY, Bentley RET, Kubes P, Archer SL. Redox Biol. 2021 Dec 24;49:102225 (online ahead of print).

Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology.

Read AD*, Bentley RET*, Archer SL, Dunham-Snary KJ. Redox Biol. 2021 Oct 12;47:102164 (online ahead of print).

The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria.

Bentley RET, Hindmarch CCT, Dunham-Snary KJ, Snetsinger B, Mewburn JD, Thébaud A, Lima PDA, Thébaud B, Archer SL. Genomics. 2021 Sep;113(5):3128-3140.

Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.

Wu D, Dasgupta A, Read AD, Bentley RET, Motamed M, Chen KH, Al-Qazazi R, Mewburn JD, Dunham-Snary KJ, Alizadeh E, Tian L, Archer SL. Free Radic Biol Med. 2021 Jan 12:S0891-5849(21)00001-0.

Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.

Theilmann AL, Hawke LG, Hilton LR, Whitford MKM, Cole DV, Mackeil JL, Dunham-Snary KJ, Mewburn J, James PD, Maurice DH, Archer SL, Ormiston ML. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2605-2618.

Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen-Sensing, Metabolism and Dynamics.

Dasgupta A, Wu D, Tian L, Xiong PY, Dunham-Snary KJ, Chen KH, Alizadeh E, Motamed M, Potus F, Hindmarch CCT, Archer SL. Compr Physiol. 2020 Mar 12;10(2):713-765.

Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Dunham-Snary KJ, Archer SL.Circ Res. 2019 Sep 27;125(8):e35-e36.

Ndufs2, a Core Subunit of Mitochondrial Complex I, is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL. Circ Res. 2019 Jun 7;124(12):1727-1746.

Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.

Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL. Front Cardiovasc Med. 2019 Jan 25;5:195.

Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo.

Dunham-Snary KJ, Sandel MW, Sammy MJ, Westbrook DG, Xiao R, McMonigle RJ, Ratcliffe WF, Penn A, Young ME, Ballinger SW. EBioMedicine. 2018 Oct;36:316-328.

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Depp Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.

Potus F, Hindmarch CCT, Dunham-Snary KJ, Stafford J, Archer SL. Int J Mol Sci. 2018 Sep 12;19(9):2730.

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.

Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary KJ, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL. Circulation. 2018 Jul 17;138(3):287-304.

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.

Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary KJ, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. J Mol Med (Berl). 2017 Apr;95(4):381-393.

MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype. Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary KJ, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL. Am J Respir Crit Care Med. 2017 Feb 15;195(4):515-529.

Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.

Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL. Chest. 2017 Jan;151(1):181-192.

The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease.

King AL, Mantena SK, Andringa KK, Millender-Swain T, Dunham-Snary KJ, Oliva CR, Griguer CE, Bailey SM. Redox Biol. 2016 Oct;9:188-197.

Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.

Krzywanski DM, Moellering DR, Westbrook DG, Dunham-Snary KJ, Brown J, Bray AW, Feeley KP, Sammy MJ, Smith MR, Schurr TG, Vita JA, Ambalavanan N, Calhoun D, Dell'Italia L, Ballinger SW. Circ Cardiovasc Genet. 2016 Feb;9(1):26-36.

A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.

Dunham-Snary KJ, Hong ZG, Xiong PY, Del Paggio JC, Herr JE, Johri AM, Archer SL. Pflugers Arch. 2016 Jan;468(1):43-58.

GENETICS. Mitochondrial-nuclear DNA mismatch matters.

Dunham-Snary KJ, Ballinger SW. Science. 2015 Sep 25;349(6255):1449-50.

A method for assessing mitochondrial bioenergetics in whole white adipose tissues.

Dunham-Snary KJ, Sandel MW, Westbrook DG, Ballinger SW. Redox Biol. 2014 Apr 18;2:656-60.

Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility.

Dunham-Snary KJ, Ballinger SW. Free Radic Biol Med. 2013 Dec;65:1229-1237.

Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.

Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, Kesterson RA, Dell'italia LJ, Darley-Usmar VM, Welch DR, Ballinger SW. Biochem J. 2013 Oct 15;455(2):157-67.

The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics.

Krzywanski DM, Moellering DR, Fetterman JL, Dunham-Snary KJ, Sammy MJ, Ballinger SW. Lab Invest. 2011 Aug;91(8):1122-35.