Publications

Electron leak from the mitochondrial electron transport chain complex I at site IQ is crucial for oxygen-sensing in rabbit and human ductus arteriosus.

Read AD, Bentley RET, Martin AY, Mewburn JD, Alizadeh E, Wu D, Lima PDA, Dunham-Snary KJ, Thébaud B, Sharp W, Arrcher SL. J Am Heart Assoc. 2023; 12:e029131.

The haplogroup gap: The ticking time bomb of cardiometabolic disease in developing nations.

Dunham-Snary KJ. Open Access Government. 2023 Jan 20; 142-143.

Medium-chain acyl-CoA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment.

Mason E, Hindmarch CCT, Dunham-Snary KJ. Endocrin Diabetes Metab. 2023 Jan 6;1:e385.

SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.

Archer SL, Dasgupta A, Chen KH, Wu D, Baid K, Mamatis JE, Gonzalez V, Read AD, Bentley RET, Martin AY, Mewburn JD, Dunham-Snary KJ, Evans GA, Levy G, Jones O, Al-Qazazi R, Ring B, Alizadeh E, Hindmarch CCT, Rossi J, Lima PDA, Falzarano D, Banerjee A, Colpitts CC. Redox Biol. 2022.

Mitochondria in human neutrophils mediate killing of staphylococcus aureus.

Dunham-Snary KJ, Surewaard BGJ, Mewburn JD, Lima PDA, Jones O, Al-Qazazi R, Martin AY, Bentley RET, Kubes P, Archer SL. Redox Biol. 2022.

The comprehensive transcriptome of human ductus arteriosus smooth muscle cells (hDASMC).

Bentley RET, Hindmarch CCT, Dunham-Snary KJ, Snetsinger B, Mewburn JD, Thébaud A, Lima PDA, Thébaud B, Archer SL. Data in Brief. 2022.

Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology.

Read AD*, Bentley RET*, Archer SL, Dunham-Snary KJ. Redox Biol. 2021.

The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria.

Bentley RET, Hindmarch CCT, Dunham-Snary KJ, Snetsinger B, Mewburn JD, Thébaud A, Lima PDA, Thébaud B, Archer SL. Genomics. 2021.

Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.

Wu D, Dasgupta A, Read AD, Bentley RET, Motamed M, Chen KH, Al-Qazazi R, Mewburn JD, Dunham-Snary KJ, Alizadeh E, Tian L, Archer SL. Free Radic Biol Med. 2021.

Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.

Theilmann AL, Hawke LG, Hilton LR, Whitford MKM, Cole DV, Mackeil JL, Dunham-Snary KJ, Mewburn J, James PD, Maurice DH, Archer SL, Ormiston ML. Arterioscler Thromb Vasc Biol. 2020.

Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen-Sensing, Metabolism and Dynamics.

Dasgupta A, Wu D, Tian L, Xiong PY, Dunham-Snary KJ, Chen KH, Alizadeh E, Motamed M, Potus F, Hindmarch CCT, Archer SL. Compr Physiol. 2020.

Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Dunham-Snary KJ, Archer SL.Circ Res. 2019.

Ndufs2, a Core Subunit of Mitochondrial Complex I, is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL. Circ Res. 2019.

Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.

Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL. Front Cardiovasc Med. 2019.

Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo.

Dunham-Snary KJ, Sandel MW, Sammy MJ, Westbrook DG, Xiao R, McMonigle RJ, Ratcliffe WF, Penn A, Young ME, Ballinger SW. EBioMedicine. 2018.

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Depp Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.

Potus F, Hindmarch CCT, Dunham-Snary KJ, Stafford J, Archer SL. Int J Mol Sci. 2018.

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.

Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary KJ, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL. Circulation. 2018.

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.

Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary KJ, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. J Mol Med (Berl). 2017 Apr;95(4):381-393.

MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype. Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary KJ, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL. Am J Respir Crit Care Med. 2017 Feb 15;195(4):515-529.

Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.

Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL. Chest. 2017 Jan;151(1):181-192.

The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease.

King AL, Mantena SK, Andringa KK, Millender-Swain T, Dunham-Snary KJ, Oliva CR, Griguer CE, Bailey SM. Redox Biol. 2016 Oct;9:188-197.

Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.

Krzywanski DM, Moellering DR, Westbrook DG, Dunham-Snary KJ, Brown J, Bray AW, Feeley KP, Sammy MJ, Smith MR, Schurr TG, Vita JA, Ambalavanan N, Calhoun D, Dell'Italia L, Ballinger SW. Circ Cardiovasc Genet. 2016 Feb;9(1):26-36.

A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.

Dunham-Snary KJ, Hong ZG, Xiong PY, Del Paggio JC, Herr JE, Johri AM, Archer SL. Pflugers Arch. 2016 Jan;468(1):43-58.

GENETICS. Mitochondrial-nuclear DNA mismatch matters.

Dunham-Snary KJ, Ballinger SW. Science. 2015 Sep 25;349(6255):1449-50.

A method for assessing mitochondrial bioenergetics in whole white adipose tissues.

Dunham-Snary KJ, Sandel MW, Westbrook DG, Ballinger SW. Redox Biol. 2014 Apr 18;2:656-60.

Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility.

Dunham-Snary KJ, Ballinger SW. Free Radic Biol Med. 2013 Dec;65:1229-1237.

Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.

Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, Kesterson RA, Dell'italia LJ, Darley-Usmar VM, Welch DR, Ballinger SW. Biochem J. 2013 Oct 15;455(2):157-67.

The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics.

Krzywanski DM, Moellering DR, Fetterman JL, Dunham-Snary KJ, Sammy MJ, Ballinger SW. Lab Invest. 2011 Aug;91(8):1122-35.